Choose Payment Option
Pay at store or pay when you receive the items.
Oxygen is the most crucial factor which is essential for life of all living organism. No one can live on earth without oxygen but it can be harmful when it becomes toxic. Oxygen is a highly reactive atom that is capable of becoming part of potentially damaging molecules commonly called “free radicals.” Free radicals have tendency of attacking the healthy cells of the body, causing them to lose their structure and function. Cell damage caused by free radicals appears to be a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, cataracts, immune system decline, and brain dysfunction. Overall, free radicals have been implicated in the pathogenesis of at least 50 diseases. In plants and animals these free radicals are deactivated by antioxidants.
ANTIOXIDANTS AND THEIR TYPES
Antioxidants are defined as “The substance that delays, prevents or removes oxidative damage to a target molecule”.In the same year defined antioxidants as “substance that directly scavenges ROS (Reactive Oxygen Species) or indirectly acts as inhibitor of ROS production”. Compounds which have the ability, after scavenging the radical, to form a new radical that is stable through intramolecular hydrogen bonding on further oxidation are called as antioxidants.
"Antioxidants‟ are substances that neutralize the actions of free radicals. Every cell in nature is endowed naturally with several protective mechanisms against any harmful effects of free radicals: superoxide dismutase (SOD), glutathione reductase, glutathione peroxidases are the enzymatic antioxidants. Tocopherol (vitamin E) is an essential nutrient which acts as a chain- breaking antioxidant preventing the propagation of free radical reactions in all cell membranes in the human body. Ascorbic acid (vitamin C) is also an antioxidant which protects against free radicals. Carotenoids, flavonoids and polyphenols, α-lipoic acid, glutathione etc are the other non-enzymatic antioxidants. These antioxidants plays diverse physiological role in body by inhibiting the process of oxidation, even at relatively small concentration.
MAJOR ANTIOXIDANTS & THEIR SOURCES
There are various food items contains antioxidants-
Vitamin C - Fruits and vegetables, eg. Oranges, guava, amla, pineapple, tomatoes, spinach, carrots.
Vitamin E - Vegetable oils eg, soybean, corn, and safflower and vegetable oil products eg, margarine, whole grains, wheat germ, nuts and seeds, and green, leafy vegetables.
Carotene - Yellow-orange fruits (eg, cantaloupe) and vegetables (eg, carrots) and green, leafy vegetables.
Polyphenolic antioxidants - Tea, coffee, soy, fruit, olive oil, chocolate, cinnamon, oregano and red wine.
ANTIOXIDANTS AND THEIR ROLE IN PREVENTION OF DISEASES
CAROTENOIDS
Carotenoids are a family of pigmented compounds that are synthesized by plants and microorganisms but not animals. Carotenoids in plants protect photo damage by contributing to the photosynthetic machinery. In human diet fruits and vegetables constitute the major sources of carotenoid. Carotenoids are thought to be responsible for the beneficial properties of fruits and vegetables in preventing human diseases including cardiovascular diseases, cancer and other chronic diseases. They are important dietary sources of vitamin A. In humans and animals carotenoids play an important role in protection against photooxidative processes by acting as oxygen and peroxyl radical scavengers. Carotene is a fat soluble member of the carotenoids which are considered provitamins because they can be converted to active vitamin A. Betacarotene is converted to retinol, which is essential for vision. It is a strong antioxidant and is the best quencher of singlet oxygen.
LYCOPENE
Lycopene, a member of the carotenoid family of phytochemicals is a lipid soluble antioxidant that is synthesized by many plants and microorganisms. Lycopene is not synthesized by animals and human. It is responsible for the red color of many fruits and vegetables such as the tomatoes. Lycopene have a half life of about 2–3 days and is a predominant carotenoid in human plasma. The antioxidant property of lycopene has been the main focus of research to study its biological role. Lycopene has been found preventive against cancer, through various diseases. A follow up met analysis of 72 different studies in 1999 showed that lycopene intake as well as serum lycopene levels were inversely related to several cancers including prostate, breast, cervical, ovarian, and liver and other organ sites. [23] Lycopene protects cells against oxidative damage and there by prevent or reduces the risk of several cancers.
POLYPHENOLS
Polyphenols are produced by plants typically as a defense against herbivores and various stresses in general. In Western countries, polyphenol intake is approx. 0.4-1g/d and capita, with higher intake for persons following a vegetarian diet. Food sources that are especially rich in polyphenols include potato, plums, leafy vegetables, whole grain products, and coffee.
Like as phenolic acids, flavonoids are secondary metabolites of plants with polyphenolic structure thus flavonoid groups of poly phenolic compounds have low toxicity in mammals and are widely distributed in plant kingdom. Major dietary sources of Flavonoides in the form of flavonols, flavones, isoflavones, flavonones are, tea, red wine, apple, tomato, cherry, onion, thyme, parsley, soyabeans, and other legumes, grape fruit, orange, lemon, ginkgo, and neem.
VITAMIN C
Ascorbic acid, commonly known as vitamin C plays significant functions in the human body, though its function at the cellular level is not very clear. Vitamin C is needed for collagen synthesis, the protein that serves so many connective functions in the body. Among the body‟s collagen-containing materials and structures are the framework of bone, gums and binding materials in skin muscle or scar tissue. Production of certain hormones and of neurotransmitters and the metabolism of some amino acids and vitamins require vitamin C. This vitamin also helps the liver in the detoxification of toxic substances in the system, and the blood in fighting infections. Ascorbic acid is important in the proper function of the immune system. As an antioxidant, it reacts with compounds like histamines and peroxides to reduce inflammatory symptoms. Its antioxidant property is associated with the reduction of cancer incidences.
VITAMIN E
Vitamin E chemically known as tocopherol is one of the most important lipid-soluble primary defense antioxidants. It is a generic term used for several naturally occurring tocopherols and tocotrienols. In its function as a chain-breaking antioxidant, vitamin E rapidly transfers its phenolic H-atom to a lipid peroxyl radical, converting it into a lipid hydroperoxide and a vitamin E radical. Palm vitamin E (30% tocopherols, 70% tocotrienols) has been extensively researched for its nutritional and health properties for treatment of cancer.
Name | Comments | Date |
---|